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Uric acid and renal function in multiple sclerosis
E L Kanabrocki1, M D Ryan, R C Hermida
1Nuclear Medicine Service, Edward Hines Jr., VA Hospital, Hines, IL 60141, USA. Eugene.Kanabrocki@va.gov
La Clinica Terapeutica
|April 11, 2008
Summary
Multiple Sclerosis patients, particularly females, show reduced kidney function indicated by lower creatinine and uric acid clearances. This suggests potential renal dysfunction in female MS patients, possibly contributing to disease prevalence.
Area of Science:
- Nephrology
- Neurology
- Chronobiology
Background:
- Multiple Sclerosis (MS) is a chronic neurological disease.
- Circadian rhythms play a role in physiological processes, including kidney function.
- Potential sex-based differences in MS pathogenesis are not fully understood.
Purpose of the Study:
- To investigate the circadian patterns of creatinine and uric acid clearance in individuals with MS.
- To compare renal function between MS patients and healthy controls, with attention to sex differences.
Main Methods:
- Circadian blood and urine samples were collected from 11 MS patients (6 female, 5 male) and controls.
- Creatinine and uric acid clearances were calculated and standardized.
- Analysis included various analytes such as insulin, IL-6, and nitric oxide (NO).
Main Results:
- MS females exhibited significantly lower creatinine clearance compared to female controls (63+/-22 vs. 108+/-18 ml/min).
- Uric acid clearance was also reduced in MS females (6.9+/-2.4 vs. 10.5+/-4.4 ml/min).
- MS males showed higher uric acid clearance than male controls (7.0+/-4.5 vs. 4.0+/-1.0 ml/min).
Conclusions:
- Reduced creatinine and uric acid clearances in MS females suggest potential renal dysfunction.
- These findings may offer insights into the mechanisms of renal dysfunction in female MS patients.
- Sex-specific renal alterations could be a factor in the higher prevalence of MS in females.
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