Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Uric acid and renal function in multiple sclerosis.

E L Kanabrocki1, M D Ryan, R C Hermida

  • 1Nuclear Medicine Service, Edward Hines Jr., VA Hospital, Hines, IL 60141, USA. Eugene.Kanabrocki@va.gov

La Clinica Terapeutica
|April 11, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lipoprotein binding to anionic biopolyelectrolytes and the effect of glucose on nanoplaque formation in arteriosclerosis and Alzheimer's disease.

Advances in colloid and interface science·2016
Same author

Combined lowering of low grade systemic inflammation and insulin resistance in metabolic syndrome patients treated with Ginkgo biloba.

Atherosclerosis·2014
Same author

Anionic biopolyelectrolytes of the syndecan/perlecan superfamily: physicochemical properties and medical significance.

Advances in colloid and interface science·2014
Same author

Sleep-time ambulatory blood pressure as a novel therapeutic target for cardiovascular risk reduction.

Journal of human hypertension·2014
Same author

Omega-3 fatty acids: benefits for cardio-cerebro-vascular diseases.

Atherosclerosis·2012
Same author

Hs-CRP may be associated with white blood cell count in metabolic syndrome patients treated with Ginkgo biloba.

Atherosclerosis·2011
Same journal

Effectiveness of Focal Muscle Vibration in Post-Anterior Cruciate Ligament Reconstruction Rehabilitation: A Case Report.

La Clinica terapeutica·2026
Same journal

Violence Against Women as a Public-Health Exposure: Biological Embedding, Medico-Legal Caution and Precision Prevention in the EpiWe Framework.

La Clinica terapeutica·2026
Same journal

Suicide of the Work-Disabled Individual Affected by Neoplasia with Unfavorable Prognosis: Evidence-Based Legal Medicine in Reconstructing the Causal Link.

La Clinica terapeutica·2026
Same journal

The therapeutic potential of N-acetylcysteine across multiple organ systems: a narrative review.

La Clinica terapeutica·2026
Same journal

Mesotherapy in Pain Management in Primary Care: A Narrative Review and Practice-Oriented Appraisal.

La Clinica terapeutica·2026
Same journal

Bone Marrow Edema in Rheumatic Diseases: Incidence, Diagnosis, and Therapeutic Implications. A Narrative Review.

La Clinica terapeutica·2026
See all related articles

Multiple Sclerosis patients, particularly females, show reduced kidney function indicated by lower creatinine and uric acid clearances. This suggests potential renal dysfunction in female MS patients, possibly contributing to disease prevalence.

Area of Science:

  • Nephrology
  • Neurology
  • Chronobiology

Background:

  • Multiple Sclerosis (MS) is a chronic neurological disease.
  • Circadian rhythms play a role in physiological processes, including kidney function.
  • Potential sex-based differences in MS pathogenesis are not fully understood.

Purpose of the Study:

  • To investigate the circadian patterns of creatinine and uric acid clearance in individuals with MS.
  • To compare renal function between MS patients and healthy controls, with attention to sex differences.

Main Methods:

  • Circadian blood and urine samples were collected from 11 MS patients (6 female, 5 male) and controls.
  • Creatinine and uric acid clearances were calculated and standardized.
  • Analysis included various analytes such as insulin, IL-6, and nitric oxide (NO).

Related Experiment Videos

Main Results:

  • MS females exhibited significantly lower creatinine clearance compared to female controls (63+/-22 vs. 108+/-18 ml/min).
  • Uric acid clearance was also reduced in MS females (6.9+/-2.4 vs. 10.5+/-4.4 ml/min).
  • MS males showed higher uric acid clearance than male controls (7.0+/-4.5 vs. 4.0+/-1.0 ml/min).

Conclusions:

  • Reduced creatinine and uric acid clearances in MS females suggest potential renal dysfunction.
  • These findings may offer insights into the mechanisms of renal dysfunction in female MS patients.
  • Sex-specific renal alterations could be a factor in the higher prevalence of MS in females.