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Isolation of Bacillus stearothermophilus constituent that suppresses mouse mixed leukocyte reaction in vitro
Y Kohama1, N Murayama, K Tanaka
1Faculty of Pharmaceutical Sciences, Osaka University, Japan.
Chemical & Pharmaceutical Bulletin
|December 1, 1991
Abstract:
A novel immunosuppressant, Fr.5-B, has been isolated from the debris of Bacillus stearothermophilus UK563 autolysate. Fr.5-B suppressed mouse mixed leukocyte reaction at doses ranging from 10(-4) to 1 microgram/ml, but not proliferation stimulated by concanavalin A and lipopolysaccharide.