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Related Concept Videos

Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Testosterone: Functions and Regulation01:26

Testosterone: Functions and Regulation

The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
Infertility in Males01:23

Infertility in Males

Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
Male Sexual Response: Erection & Ejaculation01:17

Male Sexual Response: Erection & Ejaculation

Sexual stimulation can take various forms, such as physical touch and visual or auditory cues. When this happens, the parasympathetic reflex in the sacral portion of the spinal cord is activated. This reflex stimulates the release of nitric oxide (NO), which then dilates the arterioles in the penis, increasing blood flow to the erectile tissues - the corpora cavernosa and corpus spongiosum.
The blood filling the erectile tissues compresses the veins, which helps to prevent blood from leaving...
Spermatogenesis01:41

Spermatogenesis

Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male reproductive...
Sperm Transport01:15

Sperm Transport

The journey of sperm from its origin to the point of ejaculation begins within the seminiferous tubules of the testis. Here, Sertoli cells produce fluid that propels non-motile sperm through a series of conduits, starting with the straight tubules leading to the rete testis. This interconnected network of tubules acts as the initial pathway for sperm, guiding them into the efferent ductules and then into the epididymis for maturation.
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Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
04:22

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

Different testosterone levels are associated with ejaculatory dysfunction.

Giovanni Corona1, Emmanuele A Jannini, Edoardo Mannucci

  • 1Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy.

The Journal of Sexual Medicine
|April 11, 2008
PubMed
Summary
This summary is machine-generated.

Testosterone (T) appears to facilitate ejaculatory reflex control. Lower T levels are linked to delayed ejaculation (DE), while higher levels are associated with premature ejaculation (PE) in younger men, suggesting T

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Published on: December 8, 2023

Area of Science:

  • Endocrinology
  • Urology
  • Sexual Medicine

Background:

  • The precise role of testosterone (T) in the development of ejaculatory symptoms remains unclear.
  • Understanding T's influence is crucial for diagnosing and treating sexual dysfunction.

Purpose of the Study:

  • To investigate the association between testosterone levels and ejaculatory dysfunction, specifically premature ejaculation (PE) and delayed ejaculation (DE).
  • To compare testosterone levels in men with PE or DE to those without ejaculatory issues.

Main Methods:

  • Studied 2,437 male patients with sexual dysfunction.
  • Assessed hormonal parameters, including total testosterone (TT).
  • Defined hypogonadism as TT below 10.4 nmol/L.

Main Results:

  • PE was reported by 25.9% and DE by 4.4% of patients.
  • Younger men (25-40) with PE had higher TT and free testosterone (FT) than other groups.
  • Older men (55-70) with DE showed lower TT and FT levels.
  • Hypogonadism prevalence was lowest in PE (12%) and highest in DE (26%).

Conclusions:

  • Testosterone (T) appears to play a facilitatory role in controlling the ejaculatory reflex.
  • Both central and peripheral mechanisms may explain this T-ejaculation link.
  • Further research is ongoing to confirm T's role and explore androgen administration for DE.