What causes hidradenitis suppurativa?

Area of Science:

• Dermatology
• Pathobiology
• Inflammatory Skin Disorders

Background:

• Hidradenitis suppurativa (HS) is a common, chronic, and debilitating inflammatory skin appendage disorder.
• The exact cause of HS remains unknown, leading to ongoing debates about its nomenclature and pathogenesis.
• The burden of disease associated with HS is often underestimated.

Purpose of the Study:

• To discuss the pathobiology of hidradenitis suppurativa.
• To explore potential pathogenesis pathways contributing to HS.
• To foster a consensus on the molecular mechanisms underlying HS.

Main Methods:

• A virtual debate among HS experts was convened.
• Potential pathogenesis pathways for HS were comprehensively dissected.
• Existing literature and expert opinions were synthesized.

Main Results:

• Experts presented complementary, rather than mutually exclusive, pathogenesis scenarios for HS.
• An emerging consensus on the pathobiology of HS was observed.
• The discussion moved beyond terminological disputes to focus on scientific understanding.

Conclusions:

• A deeper understanding of HS pathobiology is crucial for developing effective therapies.
• A renaissance in basic HS research is needed to address open questions.
• Collaborative efforts and constructive debate are vital for advancing HS knowledge.