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Related Concept Videos

Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
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Autoimmune Disorders01:29

Autoimmune Disorders

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Concept and Mechanism of Autoimmune Diseases
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Related Experiment Videos

What causes hidradenitis suppurativa?

H Kurzen, I Kurokawa, G B E Jemec

    Experimental Dermatology
    |April 11, 2008
    PubMed
    Summary

    Hidradenitis suppurativa (HS), a chronic inflammatory skin condition, is being re-examined to understand its underlying causes. Experts are discussing potential pathogenesis pathways to improve diagnosis and treatment.

    Related Experiment Videos

    Area of Science:

    • Dermatology
    • Pathobiology
    • Inflammatory Skin Disorders

    Background:

    • Hidradenitis suppurativa (HS) is a common, chronic, and debilitating inflammatory skin appendage disorder.
    • The exact cause of HS remains unknown, leading to ongoing debates about its nomenclature and pathogenesis.
    • The burden of disease associated with HS is often underestimated.

    Purpose of the Study:

    • To discuss the pathobiology of hidradenitis suppurativa.
    • To explore potential pathogenesis pathways contributing to HS.
    • To foster a consensus on the molecular mechanisms underlying HS.

    Main Methods:

    • A virtual debate among HS experts was convened.
    • Potential pathogenesis pathways for HS were comprehensively dissected.
    • Existing literature and expert opinions were synthesized.

    Main Results:

    • Experts presented complementary, rather than mutually exclusive, pathogenesis scenarios for HS.
    • An emerging consensus on the pathobiology of HS was observed.
    • The discussion moved beyond terminological disputes to focus on scientific understanding.

    Conclusions:

    • A deeper understanding of HS pathobiology is crucial for developing effective therapies.
    • A renaissance in basic HS research is needed to address open questions.
    • Collaborative efforts and constructive debate are vital for advancing HS knowledge.