Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Teratogenicity

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

Fetal Circulation

Fetal Circulation

Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...

Disorders of Hemostasis

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...

Development of Blood Vessels

Development of Blood Vessels

The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...

Venous Thrombosis III: Interprofessional Care

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Age-related and disease-specific changes in B-cell profiles in older adults with immune thrombocytopenia.

Frontiers in immunology·2026

Same author

Vaccine-induced immune thrombocytopenia and thrombosis after mRNA-1273 booster vaccination.

Thrombosis research·2022

Same author

Targeting neonatal Fc receptor: potential clinical applications in pregnancy.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2022

Same author

Questionable benefit of intrauterine transfusion following single fetal death in monochorionic twin pregnancy.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2022

Same author

Risk factors for RhD immunisation in a high coverage prevention programme of antenatal and postnatal RhIg: a nationwide cohort study.

BJOG : an international journal of obstetrics and gynaecology·2022

Same author

New possibilities for ST analysis - A post-hoc analysis on the Dutch STAN RCT.

Early human development·2022

Search research articles

Related Experiment Video

Updated: Jul 6, 2026

Accurate and Simple Evaluation of Vascular Anastomoses in Monochorionic Placenta using Colored Dye

Accurate and Simple Evaluation of Vascular Anastomoses in Monochorionic Placenta using Colored Dye

Published on: September 5, 2011

Fetal thrombocytopenia.

L Porcelijn¹, E S A Van den Akker, D Oepkes

¹Department of Immunohaematology Diagnostic Services, Sanquin Diagnostic Services (CLB), Amsterdam, The Netherlands.

Seminars in Fetal & Neonatal Medicine

|April 11, 2008

Summary

This summary is machine-generated.

Maternal alloantibodies cause fetal thrombocytopenia, leading to bleeding and potential death. Intravenous immunoglobulin treatment in subsequent pregnancies is crucial for prevention.

Related Experiment Videos

Last Updated: Jul 6, 2026

Accurate and Simple Evaluation of Vascular Anastomoses in Monochorionic Placenta using Colored Dye

Accurate and Simple Evaluation of Vascular Anastomoses in Monochorionic Placenta using Colored Dye

Published on: September 5, 2011

Area of Science:

Immunology
Perinatology
Hematology

Background:

Fetal thrombocytopenia often results from maternal alloantibodies targeting fetal platelets.
This condition, fetal and neonatal alloimmune thrombocytopenia, causes bleeding in newborns, including dangerous intracranial hemorrhage.
Severe cases can lead to significant disability or fetal demise, posing a challenge for future pregnancies.

Purpose of the Study:

To outline the primary cause of fetal thrombocytopenia.
To describe the clinical presentation and severity of fetal and neonatal alloimmune thrombocytopenia.
To highlight the importance of preventive treatment in subsequent pregnancies.

Main Methods:

Review of the pathophysiology of fetal thrombocytopenia.
Description of clinical detection and consequences of the condition.
Discussion of current preventive strategies.

Main Results:

Maternal alloantibodies are the most common cause of fetal platelet destruction.
Bleeding, particularly intracranial hemorrhage, is a severe manifestation in affected neonates.
Preventive treatment is essential for managing risk in subsequent pregnancies.

Conclusions:

Fetal and neonatal alloimmune thrombocytopenia necessitates early detection and management.
Maternal intravenous immunoglobulin administration is the standard preventive treatment.
Effective management aims to mitigate the risks of bleeding and improve fetal outcomes.