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Updated: Jul 6, 2026

Spatio-Temporal Manipulation of Small GTPase Activity at Subcellular Level and on Timescale of Seconds in Living Cells
10:27

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Published on: March 9, 2012

Transglutaminase-catalyzed transamidation: a novel mechanism for Rac1 activation by 5-hydroxytryptamine2A receptor

Y Dai1, N L Dudek, T B Patel

  • 1Neuroscience Program, Loyola University Medical Center, Maywood, Illinois, USA.

The Journal of Pharmacology and Experimental Therapeutics
|April 11, 2008
PubMed
Summary

Serotonin activates Rac1 in neurons through transglutaminase (TGase) and 5-hydroxytryptamine (HT)(2A) receptors. This novel signaling pathway involves TGase-catalyzed serotonin binding to Rac1, transiently increasing its activity.

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