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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...

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Challenges of kidney function evaluation in pregnancy.

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Creatinine, cystatin C or both to estimate glomerular filtration rate in kidney transplant recipients?

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Related Experiment Video

Updated: Jul 6, 2026

Measurement of BK-polyomavirus Non-Coding Control Region Driven Transcriptional Activity Via Flow Cytometry
11:54

Measurement of BK-polyomavirus Non-Coding Control Region Driven Transcriptional Activity Via Flow Cytometry

Published on: July 13, 2019

Polyomavirus in renal transplantation: a hot problem.

Catherine Bonvoisin1, Laurent Weekers, Patricia Xhignesse

  • 1Department of Nephrology and Renal Transplantation, University Hospitals Liege, Belgium. catherine.bonvoisin@chu.ulg.ac.be

Transplantation
|May 24, 2008
PubMed
Summary

BK virus (BKV) infection is a serious complication after kidney transplants, affecting 1-5% of recipients. Early detection and reduced immunosuppression are key to managing BK nephropathy (BKVN) and preserving graft function.

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Murine Kidney Transplant Technique
08:58

Murine Kidney Transplant Technique

Published on: October 20, 2015

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Last Updated: Jul 6, 2026

Measurement of BK-polyomavirus Non-Coding Control Region Driven Transcriptional Activity Via Flow Cytometry
11:54

Measurement of BK-polyomavirus Non-Coding Control Region Driven Transcriptional Activity Via Flow Cytometry

Published on: July 13, 2019

Murine Kidney Transplant Technique
08:58

Murine Kidney Transplant Technique

Published on: October 20, 2015

Area of Science:

  • Nephrology
  • Virology
  • Transplantation Immunology

Background:

  • Polyomavirus BK (BKV) is a significant post-kidney transplant complication.
  • BK nephropathy (BKVN) affects 1-5% of renal transplant recipients with a poor prognosis.
  • Risk factors include immunosuppression levels, donor/recipient serostatus, and HLA-C7 absence.

Purpose of the Study:

  • To review the epidemiology, diagnosis, and management of BK virus nephropathy (BKVN) in kidney transplant recipients.
  • To highlight the importance of risk factors and diagnostic tools for BKVN.
  • To outline current treatment strategies for BKVN.

Main Methods:

  • Review of current literature on BKVN.
  • Discussion of diagnostic methods including biopsy, immunohistochemistry, urinary decoy cells, and BKV DNA PCR.
  • Analysis of treatment options, including immunosuppression reduction and antiviral therapies.

Main Results:

  • Kidney transplant recipients are at risk for BKVN, with poor outcomes if untreated.
  • Biopsy with immunohistochemistry is the gold standard for BKVN diagnosis.
  • Urinary decoy cells and BKV DNA PCR are valuable for predicting BKVN evolution despite poor positive predictive values.

Conclusions:

  • Reducing immunosuppressive therapy is the primary treatment for BKVN.
  • Cidofovir and leflunomide are options for progressive BKVN.
  • Retransplantation is feasible after BKVN with careful management to minimize recurrence risk.