Related Experiment Video
Updated: Jul 6, 2026
Retinal Pathophysiological Evaluation in a Rat Model
Published on: May 6, 2022
Retinal detachment: visual acuity and subretinal immunoreactive endothelin-1
M Roldán-Pallarés1, A Sadiq-Musa, R Rollin
1Department of Ophthalmology, Hospital Clinico San Carlos, Universidad Complutense de Madrid, Madrid, Spain. MRPUCMHS@telefonica.net
Purpose:
To analyze whether subretinal (SRF) endothelin-1 (ET-1) - a vasoactive, mitogenic, and pro-apoptotic peptide - levels are related to visual acuity (VA) in rhegmatogenous retinal detachment (RD).
Patients And Methods:
Sixty-six healthy patients between 42 and 70 years of age with unilateral RD, all candidates for scleral buckling surgery (PVR
Results:
Mean IR-ET-1 values were plasma, 2.91+/-0.44 pg/ml, and SRF, 10.71+/-7.95 pg/ml. Mean VA values were preoperative VA, 0.31+/-0.16; postoperative VA, 0.66+/-0.29; and VA difference, 0.35+/-0.18. Plasma IR-ET-1 showed significant (p<0.0001) negative linear correlations with preoperative VA (r=-0.52), postoperative VA (r=-0.69), and VA difference (r=-0.65). SRF IR-ET-1 showed significant (p<0.0001) negative linear correlations with preoperative VA (r=-0.48), postoperative VA (r=-0.61), and VA difference (r=-0.54). When proliferative vitreoretinopathy (PVR) was associated with RD, correlations between SRF IR ET-1 and postoperative VA (r=-0.70) and VA difference (r=-0.75) showed the highest negative values
Conclusions:
Correlations between SRF IR-ET-1 and VA were negative and higher for postoperative VA and these correlations showed the highest values when RD was associated with PVR. These findings support the idea of doing primary vitrectomy and perhaps using coadjutant pharmacologic therapy in these cases.
