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Related Experiment Video

Updated: Jul 6, 2026

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis

Published on: September 9, 2022

EVI5 is a risk gene for multiple sclerosis.

I A Hoppenbrouwers¹, Y S Aulchenko, G C Ebers

¹Department of Neurology, MS Centre ErasMS, Erasmus MC, Rotterdam, The Netherlands.

Genes and Immunity

|April 11, 2008

Summary

This summary is machine-generated.

This study identifies the EVI5 gene as a novel risk locus for multiple sclerosis (MS). Further research is needed to uncover the complete genetic basis of MS.

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Last Updated: Jul 6, 2026

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis

Published on: September 9, 2022

Area of Science:

Genetics
Immunology
Neurology

Background:

The human leukocyte antigen (HLA)-DRB1 locus is a primary genetic risk factor for multiple sclerosis (MS).
Previous genome-wide studies identified single-nucleotide polymorphisms (SNPs) in IL2RA and IL7RA associated with MS risk.
Thirteen additional SNPs showed consistent but less significant associations with MS.

Purpose of the Study:

To verify the association of previously identified SNPs with MS in a Dutch genetically isolated population.
To identify novel genetic risk factors for MS.

Main Methods:

Genotyping of SNPs in 46 MS patients and 194 controls from a Dutch population.
Replication analysis in an independent cohort of 1318 MS patients (Canadian Collaborative Project on the Genetic Susceptibility to MS).
Transmission disequilibrium testing (TDT) was employed for risk effect validation.

Main Results:

The EVI5 gene on chromosome 1 was confirmed as a novel MS risk gene, exhibiting higher odds ratios (ORs 2.01 and 1.9; P=0.01) than previously reported.
The risk effect of EVI5 was validated in a larger MS cohort, showing a weak but significant association (OR 1.15; P=0.03 and OR 1.15; P=0.04) via TDT.
Apart from the HLA locus, EVI5 emerged as a significant genetic risk factor for MS.

Conclusions:

EVI5 is confirmed as a novel genetic risk locus for multiple sclerosis.
Despite identifying EVI5, a substantial portion of the genetic underpinnings of MS remains to be elucidated.
Further genetic studies are warranted to fully understand MS susceptibility.