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PPAR Genomics and Pharmacogenomics: Implications for Cardiovascular Disease
1Department of Medicine, Washington University School of Medicine, Washington University, Saint Louis, MO 63110, USA.
Peroxisome proliferator-activated receptors (PPARs) influence cardiovascular health. PPAR pharmacogenetics offers insights for personalized cardiovascular disease therapies by examining gene variations and drug responses.
Area of Science:
- Cardiovascular Science
- Genetics
- Pharmacology
Background:
- Peroxisome proliferator-activated receptors (PPARs) are key regulators of cellular processes vital for cardiovascular health and disease.
- Pharmacologic and genetic studies have illuminated the clinical impact of PPARs and their polymorphisms on cardiovascular phenotypes.
Purpose of the Study:
- To review the current understanding of PPAR genetics and pharmacogenetics.
- To highlight the implications for personalized cardiovascular disease therapy.
Main Methods:
- Review of existing pharmacologic and genetic studies on PPARs.
- Analysis of clinical trial data and genetic association studies.
Main Results:
- PPARs play a significant role in cardiovascular regulation.
- PPAR polymorphisms are associated with abnormal cardiovascular phenotypes.
- PPAR agonists have demonstrated clinical effects.
Conclusions:
- PPAR pharmacogenetics is a rapidly advancing field with significant potential.
- Understanding PPAR genetics is crucial for individualizing cardiovascular disease treatment.
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