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Chiral separations in sub- and supercritical fluid chromatography
Debby Mangelings1, Yvan Vander Heyden
1Department of Analytical Chemistry and Pharmaceutical Technology, Vrije Universiteit Brussel, Brussels, Belgium.
Journal of Separation Science
|April 11, 2008
Summary
Sub- and supercritical fluid chromatography (SFC) is gaining popularity for pharmaceutical analysis, particularly for chiral separations. This review covers SFC applications in chiral separations from 2000 onwards.
Area of Science:
- Analytical Chemistry
- Separation Science
Background:
- Sub- and supercritical fluid chromatography (SFC) has seen increased adoption in pharmaceutical analysis.
- Chiral separations are a key area where SFC is becoming increasingly popular.
Purpose of the Study:
- To provide a comprehensive overview of chiral separation applications utilizing SFC.
- To review the scientific literature on SFC chiral separations from the year 2000 to the present.
Main Methods:
- Literature review of scientific publications.
- Focus on studies employing Sub- and supercritical fluid chromatography (SFC).
- Analysis of applications specifically related to chiral separations.
Main Results:
- SFC is a highly effective technique for various chiral separations in pharmaceutical analysis.
- The literature demonstrates a growing trend in SFC utilization for enantiomeric separations.
- Diverse examples of SFC applied to complex chiral molecules are presented.
Conclusions:
- Sub- and supercritical fluid chromatography (SFC) is a valuable and increasingly utilized technique for chiral separations in the pharmaceutical industry.
- The reviewed literature highlights the versatility and efficiency of SFC for resolving enantiomers.
- Continued research and application of SFC are expected to advance pharmaceutical analysis.
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