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Published on: February 18, 2016
[The role of dopamine D3 receptor in the amphetamine-induced conditioned place preference in mice]
Jun-Yan Zhu1, Li-Ping Chen, Lin Li
1Department of Forensic Medicine, Medical College, Xi'an Jiaotong University, Xi'an 710061, China. zhujunyan@163.com
Objective:
To study the role of dopamine D3 receptor involved in the amphetamine-induced conditioned place preference (CPP) in mice.
Methods:
The CPP was observed in D3 receptor knock-out (D3RKO) mice and C57BL/6 wild-type control mice after administration of amphetamine. The data were analyzed with a two-way ANOVA using the SPSS 13.0 software.
Results:
D3RKO mice showed a significant amphetamine-induced CPP (P<0.001), compared with the ones administered with saline in C57BL/6 control mice.
Conclusion:
The results indicate that amphetamine can produce significant CPP in dopamine D3 receptor knock-out mice, suggesting that amphetamine-induced addiction can be inhibited by dopamine D3 receptor.
