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Updated: Jul 6, 2026
Lipidomics and Transcriptomics in Neurological Diseases
Published on: March 18, 2022
Expression of monocyte chemoattractant protein-1 in brain tissue of patients with intractable epilepsy
1Department of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Objective:
To investigate the expression ofmonocyte chemoattractant protein-1 (MCP-1) in the brain tissue of patients with intractable epilepsy (IE) and to explore its role in the pathogenesis of IE.
Material:
Patients with IE were collected from the Department of Neurosurgery of several Chinese hospitals between 2002 and 2005. The average age of these 40 patients was 23.65 +/- 10.14 (X +/- SD) years (11 - 58 years), with 19 males and 21 females. In addition to the typical symptoms and distinct EEG features of epilepsy, all recruited patients met the requirements of intractable epilepsy.
Methods:
On the basis of positive results obtained from gene chip analysis, the expression of MCP-1 was first investigated in the brain tissue of IE patients (40 cases) using Western Blotting and immunohistochemistry and then compared with the controls.
Results:
Gene chip scanning demonstrated that expression of MCP-1 mRNA was upregulated in the brain tissue of patients with IE. Western Blotting and immunohistochemical experiments further confirmed that, as compared with that in the control group, expression of MCP-1 protein was significantly increased in the IE patients (p < 0.05).
Conclusion:
These results suggest that MCP-1 are involved in the pathogenesis of IE.
