[A study of histamine receptors in peripheral lymphocytes in asthmatic subjects]

The identification and quantitative analysis of specific histamine H1 and H2 receptors on lymphocytes were acquired and histamine-induced suppressor cell activity was examined by using 3H-histamine radioligand-binding assay and co-culture technique. The quantitative analysis of H2 receptors decreased on the lymphocytes of extrinsic asthmatic subjects. Peripheral-lymphocytes from asthmatic subjects generated less histamine-induced suppressor activity than did those from normal individuals. In the asthmatics, the functional suppressor-cell abnormality positively correlated with the decreased quantity of H2 receptors on the lymphocytes.