[Does histamine participate in diabetic ocular complications?]

The survey presents the results of clinical observation of the visual system and the evaluation of the level of histamine in the retina and choroid (together) and in the lens in poststreptozotocinic diabetes in Wistar tribe rats. The eye fundus exhibited vascular changes of various intensity, also opacities of the lenses were detected. In the chorio-retinal pool and in the lenses of diabetic animals the authors found an increase of the level of histamine in comparison with the control group. The investigations suggest that histamine could be the factor initiating the changes in the permeability of the blood vessels.