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Aromatase distribution in the monkey temporal neocortex and hippocampus.

Josue G Yague¹, Athena Ching-Jung Wang, William G M Janssen

¹Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, New York 10029, USA.

|April 12, 2008

Summary

Estrogen synthesis enzyme aromatase is widely found in neurons of the female rhesus monkey hippocampus and neocortex. This localization is independent of circulating estradiol levels, suggesting local estrogen production influences brain plasticity.

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Area of Science:

Neuroscience
Endocrinology
Cell Biology

Background:

Estrogen regulates neuronal plasticity in the hippocampus and neocortex.
Aromatase, the enzyme for estrogen biosynthesis, is present in the cerebral cortex.
The precise cellular distribution and regulation of neuronal aromatase remain unclear.

Purpose of the Study:

To investigate the cellular distribution of aromatase in the monkey brain.
To determine if gonadal estrogen affects neuronal aromatase expression.

Main Methods:

Immunohistochemistry was used to examine aromatase distribution.
Ovariectomized female rhesus monkeys with or without estradiol treatment were studied.

Main Results:

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Aromatase was localized in hippocampal CA1-3 pyramidal cells, dentate gyrus granule cells, and some interneurons.
Numerous neocortical pyramidal cells and a small subset of interneurons showed aromatase immunoreactivity.
Aromatase distribution patterns were similar in both estradiol-treated and untreated groups.

Conclusions:

Widespread neuronal aromatase suggests local estrogen synthesis contributes to synaptic plasticity in the monkey brain.
Aromatase localization in neurons appears independent of circulating estradiol levels.