Magnesium and its combination with cinnarizine in the long-term treatment of headache

Some of the so-called calcium antagonists are effectively applied in the prophylactic treatment of migraine. Magnesium compounds reveal some calcium- antagonistic features, which was the reason of magnesium compounds (magnesium sulphate i.m. or magnesium lactate p.o.) evaluation at chronic migraine-patients. The compounds were administered or alone or in combination with cinnarizine (in case of magnesium sulphate). Beneficial effects were registered both after application of magnesium sulphate and, more markedly, after the combination with cinnarizine. The potentiation of the effect is likely due, at least partially, to their own calcium-antagonistic features. The side-effects of the applied drugs were not registered.