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Resting-state functional connectivity reflects structural connectivity in the default mode network.

Michael D Greicius¹, Kaustubh Supekar, Vinod Menon

¹Department of Neurology, Stanford University School of Medicine, Stanford, CA 94304, USA. greicius@stanford.edu

Cerebral Cortex (New York, N.Y. : 1991)

|April 12, 2008

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Resting-state functional connectivity reflects structural brain connectivity. Combining functional MRI and diffusion tensor imaging reveals connections within the default mode network, enhancing our understanding of brain networks.

Area of Science:

Neuroimaging
Cognitive Neuroscience

Background:

Resting-state functional connectivity magnetic resonance imaging (fcMRI) is increasingly used to map brain networks.
Skepticism exists regarding whether fcMRI reflects neural connectivity or non-neural artifacts.

Purpose of the Study:

To test if resting-state functional connectivity reflects underlying structural connectivity.
To investigate connectivity within the default mode network (DMN).

Main Methods:

Combined diffusion tensor imaging (DTI) tractography with resting-state fcMRI.
Investigated connectivity in the DMN, including medial prefrontal cortex (MPFC), medial temporal lobes (MTLs), and posterior cingulate cortex (PCC)/retrosplenial cortex (RSC).

Main Results:

Related Experiment Videos

DTI revealed structural connections between MTLs and retrosplenial cortex.

DTI showed MPFC tracts connecting to the PCC.

Demonstrated that resting-state functional connectivity aligns with structural connectivity.

Conclusions:

Resting-state functional connectivity is a valid reflection of structural brain connectivity.
Combining DTI and fcMRI enriches the understanding of canonical brain networks like the DMN.