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Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients
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Dkk1 and Wnt3 interact to control head morphogenesis in the mouse

Samara L Lewis1, Poh-Lynn Khoo, R Andrea De Young

  • 1Children's Medical Research Institute, University of Sydney, Wentworthville, New South Wales, NSW 2145, Australia.

Development (Cambridge, England)
|April 12, 2008
PubMed
Summary

Loss of Dkk1 causes abnormal WNT/beta-catenin signaling, impacting cell movement during mouse gastrulation. DKK1 acts as a key antagonist, crucial for modulating WNT3 activity in head development.

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