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Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

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Published on: June 29, 2018

Oseltamivir enhances hippocampal network synchronization.

Atsushi Usami¹, Takuya Sasaki, Nobuhiro Satoh

¹Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.

Journal of Pharmacological Sciences

|April 12, 2008

Summary

Oseltamivir, an anti-influenza medication, enhances neural network synchronization in the brain. This drug discovery tool reveals novel insights into central nervous system circuit operations and neuronal communication.

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Area of Science:

Neuroscience
Pharmacology
Molecular Biology

Background:

Oseltamivir is a neuraminidase inhibitor used to treat influenza.
A mammalian neuraminidase homolog is present in the brain.
The central nervous system effects of oseltamivir are not well understood.

Purpose of the Study:

To investigate the effects of oseltamivir on central neurons.
To explore the impact of oseltamivir on neural circuit activity.

Main Methods:

Ex vivo patch-clamp recordings of hippocampal CA3 pyramidal cells.
Time-lapse multineuron calcium imaging.
Pharmacological manipulation using muscarinic receptor antagonists.

Main Results:

Oseltamivir enhanced spike synchronization between hippocampal CA3 pyramidal cells.
Oseltamivir and its active metabolite induced synchronized population bursts involving nearly all neurons.
Muscarinic receptor antagonists attenuated these synchronized bursts.

Conclusions:

Oseltamivir demonstrates a previously unknown effect on neural networks.
Oseltamivir serves as a valuable tool for studying neural circuit operations.
The drug's action involves muscarinic pathways in the central nervous system.