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Serological studies with reovirus-like enteritis agent.

N R Blacklow, P Echeverria, D H Smith

    Infection and Immunity
    |June 1, 1976
    PubMed
    Summary
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    Antibodies to human reovirus-like enteritis virus are acquired early in life, typically by 18 months. This finding was consistent across multiple testing methods, highlighting a significant association with Nebraska calf diarrhea virus antibodies.

    Area of Science:

    • Virology
    • Immunology
    • Pediatrics

    Background:

    • Human reovirus-like agents are associated with enteritis in children.
    • Nebraska calf diarrhea virus (NCDV) is antigenically related to human reovirus-like agents.
    • Understanding antibody prevalence is crucial for diagnosing and managing viral gastroenteritis.

    Purpose of the Study:

    • To determine the age distribution of antibodies to the human reovirus-like enteritis agent.
    • To compare antibody prevalence using complement-fixation (CF) and indirect immunofluorescence-staining (IIF) assays.
    • To investigate the antigenic relationship between the human agent and NCDV through antibody association.

    Main Methods:

    • Sera from 592 hospitalized children in Boston were analyzed.
    • Complement-fixation (CF) antibody testing was performed for the human agent and NCDV.

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  • Indirect immunofluorescence-staining (IIF) antibody testing was conducted for NCDV.

    • Main Results:

    • Antibody frequency showed a steep rise in children aged 6 to 18 months, indicating early acquisition.
    • The majority of children and young adults had detectable antibodies.
    • A significant association was observed between antibody prevalence for the human agent and NCDV antigens, particularly for CF assays.

    Conclusions:

    • Antibodies to the human reovirus-like enteritis agent are acquired early in childhood.
    • The study confirms the antigenic similarity between the human agent and NCDV.
    • Early antibody acquisition suggests widespread exposure to these viruses in the studied population.