Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Estimating cell depth from somatic mutations.

Adam Wasserstrom1, Dan Frumkin, Rivka Adar

  • 1Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel.

Plos Computational Biology
|April 12, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High-Fat-Diet-Induced Hyperglycemia Alters Liver Extracellular Matrix Composition in Mice Model.

Cells·2026
Same author

Human immunodeficiency virus-associated gut microbiome impacts systemic immunodeficiency and susceptibility to opportunistic gut infection.

Nature microbiology·2026
Same author

Harnessing glucocorticoid receptor antagonism to enhance the efficacy of cardiac regenerative growth factors and cytokines.

Nature cardiovascular research·2026
Same author

A fibroblast-centric network drives cold fibrosis in the tumor microenvironment of lung squamous cell carcinoma.

bioRxiv : the preprint server for biology·2025
Same author

From bench to business: translating academic advances into industry innovations.

Development (Cambridge, England)·2025
Same author

GMP-like and MLP-like Subpopulations of Hematopoietic Stem and Progenitor Cells Harboring Mutated <i>EZH2</i> and <i>TP53</i> at Diagnosis Promote Acute Myeloid Leukemia Relapse: Data of Combined Molecular, Functional, and Genomic Single-Stem-Cell Analyses.

International journal of molecular sciences·2025
Same journal

DeepMethylation: A deep learning framework for tissue-specific DNA methylation prediction and functional variant annotation.

PLoS computational biology·2026
Same journal

Redefining and estimating the early-phase reproduction ratio for epidemic outbreaks in spatially structured populations.

PLoS computational biology·2026
Same journal

Optimized phenotype definitions boost GWAS power.

PLoS computational biology·2026
Same journal

Detection, communication, and individual identification with deep audio embeddings: A case study with North Atlantic right whales.

PLoS computational biology·2026
Same journal

Exploring the structural lexicon of the Proteome via Metric Geometry.

PLoS computational biology·2026
Same journal

Linking retinal sampling in neural encoding models to temporal profiles of visual processing in humans.

PLoS computational biology·2026
See all related articles

Researchers developed a new method to estimate cell depth by analyzing microsatellite mutations. This technique reveals cell division rates in mice, offering insights into tissue turnover and stem cell activity.

Area of Science:

  • Cell biology
  • Genetics
  • Developmental biology

Background:

  • Cell depth, the number of divisions since zygote formation, is crucial for understanding multicellular organisms.
  • Current knowledge of cell depths in humans and mice is limited.

Purpose of the Study:

  • To develop and validate a method for estimating cell depth using somatic mutations.
  • To provide reliable cell depth estimates for various mouse cell types.

Main Methods:

  • Analysis of somatic mutations in microsatellites to infer cell division history.
  • Application of the method to estimate depths of mouse oocytes, B cells, and adult stem cells.

Main Results:

  • Oocyte depth estimates align with previous findings (average 29 divisions).

Related Experiment Videos

  • B cell depth shows a linear relationship with mouse age (34-79 divisions), suggesting ~1 division/day.
  • Adult stem cells exhibit lower average cell division counts, indicating relative quiescence.

    • Conclusions:

    • The novel method provides reliable cell depth estimations.
    • Findings offer insights into tissue turnover rates and stem cell behavior in mice.
    • This approach has implications for understanding human physiology and pathology.