[The clinico-anatomical aspects of myasthenia gravis]

Based on muscle biopsies from 3 patients with stage II myasthenia gravis, the morphological alterations of the neuromuscular junction and the enzymatic disorders in the muscle fibres are studied. Abnormalities in the structure of nerve-endings (tumescence, irregularities and elongations of the fibres), more collaterals for the axon and motor plate, lymphocytic infiltrates, presence of antibodies for striated muscle fibre, rendered evident by immunofluorescence, were found. The enzymatic alterations (ATP-ase, succinyl dehydrogenase) induce a disturbance in the muscular energy metabolism.