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Serum adiponectin, C-reactive protein and TNF-alpha levels in obese Korean children

Jung Yeon Shin1, Soo Young Kim, Min Jee Jeung

  • 1Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea.

Journal of Pediatric Endocrinology & Metabolism : JPEM
|April 15, 2008
PubMed

Insights

Childhood obesity is linked to inflammation. Obese children show lower adiponectin and higher C-reactive protein (CRP) and tumor necrosis factor-alpha (TNF-a) levels, indicating an inflammatory state.

Area of Science:

  • Pediatric Endocrinology
  • Immunology
  • Metabolic Disorders

Background:

  • Childhood obesity is a growing global health concern.
  • Obesity is increasingly recognized as a state of low-grade chronic inflammation.
  • Understanding inflammatory markers in obese children is crucial for early intervention.

Purpose of the Study:

  • To compare serum levels of adiponectin, C-reactive protein (CRP), and tumor necrosis factor-alpha (TNF-a) between obese and non-obese children.
  • To investigate the association between childhood obesity and specific inflammatory markers.
  • To explore correlations between these markers and metabolic parameters.

Main Methods:

  • A cohort of 103 children (73 obese, 30 non-obese) were assessed for anthropometric measurements and blood pressure.
  • Serum levels of adiponectin, high-sensitivity C-reactive protein (hs-CRP), and TNF-alpha were quantified.
  • Statistical analyses were performed to correlate marker levels with Body Mass Index (BMI), glucose, lipid profiles, and insulin resistance (HOMA-IR).

Main Results:

  • Obese children exhibited significantly lower serum adiponectin levels compared to non-obese children.
  • Serum hs-CRP and TNF-alpha levels were significantly elevated in obese children.
  • Adiponectin showed a negative correlation with BMI, fasting glucose, and HOMA-IR, while hs-CRP and TNF-alpha positively correlated with BMI.

Conclusions:

  • Childhood obesity is characterized by reduced adiponectin and increased levels of CRP and TNF-alpha.
  • These findings support the link between childhood obesity and systemic inflammatory processes.
  • The study highlights the potential role of these inflammatory markers in the pathophysiology of childhood obesity.
Abstract

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