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Updated: Jul 6, 2026

In Vitro SUMOylation Assay to Study SUMO E3 Ligase Activity
Published on: January 29, 2018
[Multiple post-translational modifications implied in the gene expression regulation: example of the sumoylation of
Y de Launoit1, C Degerny, A Wohlkonig
1UMR 8161, Institut de Biologie de Lille, CNRS, Université de Lille I, France.
Abstract:
To regulate the spatiotemporal expression of their target genes, the transcription factors undergo post-translational modifications of which the most studied is phosphorylation. Acetylation and ubiquitinylation on lysine residues also exert a role in the transcription, as it is the case for the regulation of the activity of the huge family of Ets transcription factors. Recently, sumoylation, a post-translational modification similar to ubiquitinylation, was described as playing a crucial role in the inhibition of the activity of these factors.
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