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Related Concept Videos

Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...

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Updated: Jul 6, 2026

Multiplex Cyclic Fluorescent Immunohistochemistry
04:21

Multiplex Cyclic Fluorescent Immunohistochemistry

Published on: January 26, 2024

Autoimmune markers in lymphoid malignancies.

K Sjöberg1, E B Roth, L Gustavsson

  • 1Department for Clinical Sciences, Section of Medicine, Lund University, Malmö University Hospital, Malmö, Sweden. klas.sjoberg@med.lu.se

Scandinavian Journal of Immunology
|April 15, 2008
PubMed
Summary
This summary is machine-generated.

Chronic immune stimulation is linked to non-Hodgkin lymphoma (NHL). This study found increased unspecific autoantibodies and decreased Helicobacter pylori (hp) antibodies in NHL patients, suggesting a defective immune response in lymphoid malignancies.

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Multiplex Cyclic Fluorescent Immunohistochemistry
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Draining Lymph Node Metastasis Model for Assessing the Dynamics of Antigen-Specific CD8+ T Cells During Tumorigenesis
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Published on: January 26, 2024

Area of Science:

  • Immunology
  • Oncology
  • Autoimmunity

Background:

  • Chronic immune stimulation, including Helicobacter pylori (hp) infection, Sjögren's syndrome, and coeliac disease, is implicated in non-Hodgkin lymphoma (NHL) pathogenesis.
  • The relationship between immune markers and lymphoid malignancies is complex, with bidirectional associations reported.

Purpose of the Study:

  • To investigate the prevalence of specific immune markers in patients diagnosed with lymphoid malignancies.
  • To analyze antibodies against transglutaminase type 2 (Tg2), factor XIII (FXIII), extractable nuclear antigen (ENA), and hp in NHL patients.

Main Methods:

  • Sera from 96 NHL patients were analyzed using ELISA for antibodies against guinea pig (gp) and human recombinant (hr) Tg2, hr FXIII subunit a, ENA, and hp.
  • A sex- and age-matched control group (768 individuals) was used for hp antibody analysis.
  • A separate control group of 59 blood donors was used for transglutaminase antibody analysis.

Main Results:

  • Elevated IgG antibodies against gp-Tg2 (72%) and unspecific anti-ENA-IgG (24%) were observed in NHL patients compared to controls (P < 0.001).
  • Anti-FXIII-IgA positivity was significantly higher in NHL patients (22% vs. 5% in controls; P = 0.03).
  • Lower than expected anti-hp-IgG positivity (36% in NHL vs. 54% in controls; P < 0.001) and no significant differences in specific hr-Tg2-IgA antibodies were found.

Conclusions:

  • The study indicates an increased frequency of unspecific autoantibodies in patients with lymphoid malignancies.
  • A potential defective immune response, characterized by reduced hp antibody levels, may contribute to the pathogenesis of lymphoid malignancies.
  • Findings suggest a complex interplay between immune dysregulation and the development of NHL.