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Updated: Jul 6, 2026

Cell-Free DNA Extraction of Vitreous and Aqueous Humor Specimens for Diagnosis and Monitoring of Vitreoretinal Lymphoma
Published on: January 12, 2024
Ocular adnexal lymphoid tumors: progress in need of clarification
1Harvard Medical School, Massachusetts Eye and Ear Infirmary, David G. Cogan Ophthalmic Pathology Lab, 243 Charles Street, Boston, MA 02114, USA. Fred_Jakobiec@meei.harvard.edu
Purpose:
To evaluate recent ophthalmic publications on ocular adnexal lymphomas (OALs) according to histopathologic and immunophenotypic criteria used in the diagnosis of systemic lymphomas (World Health Organization classification).
Design:
Summary and critical analysis of recent clinical and pathologic studies.
Methods:
Literature review and interpretation.
Results:
In the largest study of 353 cases of OALs published in the pathology literature, extranodal marginal zone lymphoma (EMZL) constituted 52%, follicular lymphoma 23%, mantle cell lymphoma 5%, and small cell lymphocytic and chronic lymphocytic leukemia 4%-plus a residuum of arcane entities. In smaller series of less intensively studied OALs in the ophthalmic literature, EMZLs had a higher preponderance and also were associated with a favorable prognosis. Many EMZLs seemed to arise primarily in the ocular adnexa (mucosa-associated lymphoid tissue [MALT] lymphoma should be restricted for EMZLs involving epithelial tissues).
Conclusions:
Rigorous diagnostic criteria and a proposal for a prospective multicenter study may bring further clarification to the emerging order in this set of tumors.
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