Related Experiment Video

Updated: Jul 6, 2026

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
09:53

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

Published on: July 5, 2021

Peritumoral edema and prognosis in intracranial meningioma surgery

J R Vignes1, M Sesay, K Rezajooi

  • 1Department of Neurosurgery A, University Hospital of Bordeaux, University of Bordeaux 2, Bordeaux, France. jean-rodolphe.vignes@chu-bordeaux.fr

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
|April 15, 2008
PubMed

Insights

Peritumoral brain edema (PTBE) significantly impacts intracranial meningioma prognosis. This swelling is closely linked to symptoms, surgical difficulty, and postoperative complications, highlighting the need for careful management.

Area of Science:

  • Neurosurgery
  • Oncology
  • Radiology

Background:

  • Peritumoral brain edema (PTBE) frequently accompanies intracranial meningiomas.
  • PTBE is suspected to contribute to complications associated with these tumors.

Purpose of the Study:

  • To elucidate the precise prognostic implications of PTBE in patients with intracranial meningiomas.
  • To identify factors correlating with PTBE and surgical outcomes.

Main Methods:

  • A retrospective analysis of 30 patients undergoing surgery for intracranial meningiomas over one year.
  • Evaluation of clinical and radiological data pre- and post-surgery, focusing on complications.
  • Multiple regression analysis to determine correlations between PTBE and various factors.

Main Results:

  • A significant correlation (p<0.05) was found between PTBE and presenting symptoms.
  • PTBE was associated with the tumor's arterial supply and the difficulty of surgical resection.
  • A strong link was observed between PTBE and the occurrence of postoperative complications.

Conclusions:

  • PTBE plays a significant role in the morbidity associated with intracranial meningiomas.
  • Predictive factors for challenging surgical resection were identified.
  • Emphasis is placed on the importance of preoperative medical management and postoperative follow-up for patients with PTBE.

More Related Videos

Surgical Treatment of an Endolymphatic Sac Tumor04:34

Surgical Treatment of an Endolymphatic Sac Tumor

Published on: May 26, 2023

Minimally Invasive Endoscopic Intracerebral Hemorrhage Evacuation09:01

Minimally Invasive Endoscopic Intracerebral Hemorrhage Evacuation

Published on: October 15, 2021

Related Concept Videos

Cerebral Edema ll: Pathophysiology01:22

Cerebral Edema ll: Pathophysiology

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...
Cerebral Edema l: Introduction01:19

Cerebral Edema l: Introduction

Cerebral edema is a pathological increase in brain water content that disrupts intracranial pressure regulation and impairs neurological function. Because the cranial vault is rigid, even modest increases in tissue volume can compromise cerebral perfusion, distort neural structures, and initiate secondary injury. Cerebral edema develops through four principal mechanisms: vasogenic, cytotoxic, interstitial, and ionic.Vasogenic EdemaVasogenic edema arises from disruption of the blood–brain...
Cytotoxic Edema: Pathophysiology01:21

Cytotoxic Edema: Pathophysiology

Cytotoxic edema is a form of cerebral edema characterized by intracellular swelling of neurons, astrocytes, and other glial cells. It develops when the mechanisms responsible for maintaining ionic gradients across the cell membrane become impaired. Under normal physiological conditions, the sodium–potassium ATPase actively transports sodium ions out of the cell and potassium ions into the cell, preserving osmotic balance and enabling electrical signaling. This pump requires a continuous supply...
Increased Intracranial Pressure ll: Pathophysiology01:29

Increased Intracranial Pressure ll: Pathophysiology

Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins with...
Aneurysm IV: Nursing Management01:22

Aneurysm IV: Nursing Management

Vigilant monitoring for aneurysm rupture is essential for patients undergoing aortic surgery.Preoperative Nursing ManagementContinuously monitor the patient for manifestations of aneurysm rupture, such as pallor, weakness, tachycardia, hypotension, abdominal, back, groin, or periumbilical pain, changes in consciousness, and a pulsating abdominal mass. Regularly assess the patient's peripheral pulses.Instruct the patient to consume a clear liquid diet the day before surgery and administer...
Brain Abscess l: Introduction01:26

Brain Abscess l: Introduction

A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...