Related Experiment Video

Updated: Jul 6, 2026

Detecting the Ligand-binding Domain Dimerization Activity of Estrogen Receptor Alpha Using the Mammalian Two-Hybrid Assay
09:07

Detecting the Ligand-binding Domain Dimerization Activity of Estrogen Receptor Alpha Using the Mammalian Two-Hybrid Assay

Published on: December 19, 2018

The androgen receptor as mediator of gene expression and signal transduction pathways

A C Cato1, H Peterziel

  • 1Forschungszentrum Karlsruhe, Institut für Genetik, Postfach 3640, D-76021 Karlsruhe, Germany.

Trends in Endocrinology and Metabolism: TEM
|April 15, 2008
PubMed

Insights

Androgen receptor (AR) action extends beyond gene regulation. New findings reveal AR also triggers non-genomic signaling pathways, similar to growth factor receptors, impacting cellular processes.

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Cell Signaling

Background:

  • Androgens regulate gene expression via the androgen receptor (AR), a cytoplasmic receptor translocating to the nucleus.
  • AR-mediated gene regulation involves direct DNA binding for positive effects and protein interactions for negative effects.

Purpose of the Study:

  • To investigate non-conventional roles of the androgen receptor.
  • To explore androgen receptor's involvement in non-genomic cellular processes.

Main Methods:

  • Review of recent findings on androgen receptor signaling.
  • Analysis of mechanisms underlying non-conventional receptor actions.

Main Results:

  • The androgen receptor mediates non-conventional responses previously associated with growth factor receptors.
  • These non-genomic actions primarily involve the activation of cytoplasmic kinases.

Conclusions:

  • The androgen receptor possesses both genomic and non-genomic functions.
  • AR signaling extends beyond transcriptional regulation to include modulation of cytoplasmic kinase pathways.

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