Related Experiment Video
Updated: Jul 6, 2026

Real-time Analysis of Gut-brain Neural Communication: Cortex wide Calcium Dynamics in Response to Intestinal Glucose Stimulation
Published on: December 29, 2023
Ca(2+) receptor from brain to gut: common stimulus, diverse actions
N Chattopadhyay1, T Yamaguchi, E M Brown
1Endocrine-Hypertension Division, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA.
Abstract:
An extracellular Ca(2+)-sensing receptor (CaR) plays central roles in Ca(2+) homeostasis by regulating parathyroid hormone (PTH)secretion and renal Ca(2+) handling. The CaR is also expressed in intestine and bone, where its functions in mineral metabolism are not yet well defined. The receptor is also present in various types of cells seemingly uninvolved in systemic mineral ion homeostasis (such as neuronal and glial cells in the brain and various epithelial cells), where its actions are poorly understood but might involve the regulation of local ionic homeostasis and/or diverse cellular processes, such as cellular differentiation and proliferation.
Related Concept Videos
Neural Regulation
Cholinergic Receptors: Muscarinic
The subtypes M1, M3, and M5 couple with the Gq subunit and activate the phospholipase C (PLC) activity, mobilizing intracellular Ca2+. Activation...
Parasympathetic Signaling
The effects of...
Gut-Brain Axis
Regulation of the Digestive System
The effectors in this regulation system are glands and smooth muscles. Activation of these...
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists

