Leukemia in children treated with growth hormone

An association between treatment with growth hormone (GH) and the development of leukemia was described in 1988. This perceived association is best explained by the fact that there are more children with GH deficiency (GHD) with risk factors predisposing them to leukemia than in the general population. These factors include previous cancers and their treatment, as well as co-existing conditions such as Down, Bloom and Fanconi syndromes. Examination of large databases of GH-treated individuals shows that GH-treated patients without these risk factors do not have an increased incidence of leukemia.