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Related Concept Videos

Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
General Transcription Factors01:30

General Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
MAPK Signaling Cascades01:07

MAPK Signaling Cascades

Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
Sympathetic Pathways: Collateral Ganglia and Adrenal Medulla01:27

Sympathetic Pathways: Collateral Ganglia and Adrenal Medulla

The sympathetic pathways of the collateral ganglia and adrenal medulla serve unique but interconnected roles in the sympathetic response.
Collateral Ganglia
Sympathetic preganglionic axons reach the collateral ganglia along the route of splanchnic nerves. These nerves bypass the sympathetic trunk and communicate with sympathetic postganglionic neurons housed in the prevertebral ganglia. These ganglia supply the organs of the abdominopelvic cavity.
The greater splanchnic nerve, formed by the...

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Related Experiment Video

Updated: Jul 6, 2026

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
09:07

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

Published on: May 27, 2015

Mast cell transcriptional networks.

Clifford M Takemoto1, Youl-Nam Lee, Anil G Jegga

  • 1Division of Pediatric Hematology, The Johns Hopkins University, Baltimore, MD 21205, USA. ctakemot@jhmi.edu

Blood Cells, Molecules & Diseases
|April 15, 2008
PubMed
Summary

Mast cells play key roles in immunity and disease. Understanding mast cell development is crucial for treating inflammatory conditions and cancers like mast cell leukemia.

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Last Updated: Jul 6, 2026

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
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Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays
11:31

Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays

Published on: July 4, 2018

Area of Science:

  • Immunology
  • Cell Biology
  • Hematopoiesis

Background:

  • Mast cells are implicated in inflammatory and allergic diseases such as asthma and rheumatoid arthritis.
  • Their absence impairs innate immunity against infections and parasites.
  • Abnormal mast cell proliferation can lead to mastocytosis and mast cell leukemia.

Purpose of the Study:

  • To review current understanding of mast cell differentiation.
  • To explore controversies in mast cell development and origin.
  • To identify potential therapeutic targets for mast cell disorders.

Main Methods:

  • Literature review and synthesis of existing research on mast cell biology.
  • Discussion of developmental pathways and transcriptional regulation.
  • Analysis of controversies in the field.

Main Results:

  • Mast cell activation is central to pathogenesis of various diseases.
  • Mast cells are vital for effective immune responses.
  • Dysregulated mast cell proliferation results in neoplastic disorders.

Conclusions:

  • Understanding mast cell differentiation offers insights into hematopoiesis.
  • Identifying developmental mechanisms can lead to novel therapeutic strategies.
  • Further research into mast cell origins and transcriptional programs is warranted.