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Updated: Jul 6, 2026

Fluorescent Calcium Imaging and Subsequent In Situ Hybridization for Neuronal Precursor Characterization in Xenopus laevis
Published on: February 18, 2020
Corticotropin-releasing hormone and calcium signaling in corticotropes
A K Ritchie1, Y A Kuryshev, G V Childs
1Aileen K. Ritchie and Yuri A. Kuryshev are at the Departments of Physiology and Biophysics, University of Texas Medical Branch, Galveston, TX 77550, USA.
Abstract:
Corticotropin-releasing hormone (CRH) stimulates ACTH secretion from anterior pituitary corticotropes, largely, but possibly not exclusively, via activation of the adenylyl cyclase cascade. CRH stimulates secretion by increasing Ca(2+) influx and by Ca(2+)-independent mechanisms. As Ca(2+) influx is largely regulated by membrane electrical properties, we review the effects of CRH on membrane excitability and changes in cytosolic Ca(2+). We also speculate on possible pathways for CRH modulation of exocytosis by Ca(2+) independent mechanisms.
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