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Related Concept Videos

Hematopoiesis01:21

Hematopoiesis

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The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
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Overview of Hematopoiesis01:20

Overview of Hematopoiesis

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Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
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Vitamins01:30

Vitamins

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Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
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Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

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The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
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Mineral, Vitamin and Water Absorption01:27

Mineral, Vitamin and Water Absorption

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Electrolytes are essential minerals and ions primarily obtained from the diet and absorbed through the gastrointestinal tract. Most electrolytes are absorbed in the small intestine. While the absorption of iron and calcium primarily occurs in the duodenum, calcium is also absorbed in the jejunum and ileum. In these regions, passive diffusion contributes to its absorption alongside active transport mechanisms in the duodenum. These ions can exit the enterocytes through specialized active...
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Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

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The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
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Related Experiment Video

Updated: Feb 9, 2026

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
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Vitamin D and hematopoiesis.

C M Bunce1, G Brown, M Hewison

  • 1L.R.F. Differentiation Program at Cardiff and Birmingham, UK; Department of Immunology, University of Birmingham, UK.

Trends in Endocrinology and Metabolism: TEM
|August 1, 1997
PubMed
Summary

1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] acts permissively, not deterministically, in myeloid cell differentiation. Novel vitamin D analogues enhance its antiproliferative effects for improved leukemia therapy.

Area of Science:

  • Endocrinology
  • Cell Biology
  • Hematology

Background:

  • Vitamin D(3) and its active metabolite, 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], exert nonclassic actions in various tissues.
  • 1,25(OH)(2)D(3) plays a role in modulating cell development, including hematopoiesis.

Purpose of the Study:

  • To review the mechanisms by which 1,25(OH)(2)D(3) influences cell development, particularly hematopoiesis.
  • To elucidate the role of 1,25(OH)(2)D(3) in monocyte differentiation and myeloid precursor cell maturation.
  • To discuss advancements in vitamin D analogues for leukemia therapy.

Main Methods:

  • Review of existing literature and laboratory data.
  • Analysis of the nonclassic actions of vitamin D(3).
  • Investigation of mechanisms governing cellular responsiveness to 1,25(OH)(2)D(3).

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Ex vivo Mimicry of Normal and Abnormal Human Hematopoiesis
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Main Results:

  • 1,25(OH)(2)D(3) acts as a permissive agent, not a deterministic signal, for monocyte differentiation.
  • Myeloid precursor cells utilize 1,25(OH)(2)D(3) to enter terminal maturation pathways.
  • Novel vitamin D analogues demonstrate potent antiproliferative activity with reduced hypercalcemic side effects.

Conclusions:

  • 1,25(OH)(2)D(3) is crucial for regulating hematopoiesis by enabling terminal differentiation.
  • Vitamin D analogues offer a promising therapeutic strategy for leukemia by enhancing antiproliferative effects.
  • Further research into mechanisms governing cellular responsiveness can optimize vitamin D-based therapies.