Related Experiment Video
Updated: Jul 6, 2026

Mechanisms Underlying Gut Hormone Secretion Using the Isolated Perfused Rat Small Intestine
Published on: February 26, 2019
Insulinotropic glucagonlike peptide-I(7-37)/(7-36)amide A new incretin hormone
1Hans-C. Fehmann and Joel F. Habener are at the Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02114, USA.
Abstract:
Intestinal peptide hormones, released into circulation in response to a meal, are important augmentors of the postprandial insulin release stimulated by absorbed nutrients. In this "Incretin concept" glucagon-like peptide I(7-37) plays a major role because it is the most powerful glucose-dependent insulin secretagogue described so far. Glucagonlike peptide I(7-37) also stimulates proinsulin gene expression and proinsulin biosynthesis in insulinoma cells, and it may be involved in the regulation of the intracellular insulin pool of the B cell. Recent studies show elevated levels of glucagonlike peptide I(7-37) in patients with non-insulin-dependent diabetes mellitus. The physiology and pathophysiology of the enteroinsular axis is a promising field of basic and clinical research that has a relevance to diabetes mellitus.
More Related Videos
Related Concept Videos
Glucagon-like Receptor Agonists
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by the...
Dipeptidyl Peptidase 4 Inhibitors
Oral Hypoglycemic Agents: Glinides
Glucose Homeostasis: Pancreatic Islets and Insulin Secretion
Insulin and C-peptide are co-secreted in...
Insulin: Biosynthesis, Chemistry, and Preparation
Damage or functional impairment of β-cells inhibits insulin production, leading to diabetes. Diabetes treatment primarily uses...
Hormones Regulating Blood Glucose
In addition to accelerating glucose uptake and utilization, insulin has...

