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Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
Published on: June 3, 2016
Hormonal regulation of adipose differentiation
G Ailhaud1, P Grimaldi, R Négrel
1Center for Biochemistry (CNRS UMR 134), University of Nice-Sophia Antipolis, Faculty of Sciences, Parc Valrose, 06108 Nice 2, France.
Abstract:
Adipose differentiation is a multistep process with the following sequence: adipoblasts --> preadipocytes --> adipocytes. Adipogenic agents are only involved in the terminal differentiation of preadipocytes to adipocytes by means of circulating hormones (growth hormone, glucocorticoids, or triiodothyronine) and locally produced hormones (prostacyclin). Fatty acids also behave as hormones and act as transcriptional regulators of lipid-related genes. Once differentiated, adipocytes become secretory cells able to synthetize and release an impressive number of peptide and nonpeptide compounds, suggesting a potential link between excess of adipose tissue mass and various physiopathphysiologic consequences.
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