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Updated: Jul 6, 2026

Indirect Immunofluorescence on Frozen Sections of Mouse Mammary Gland
Published on: December 1, 2015
Development of the mammary gland and lactation
1Department of Physiology, Wayne State University, School of Medicine, Detroit, MI 48201, USA.
Abstract:
Many hormones, growth factors, and protooncogene products involved in mammary development and lactation have been identified; however, the mechanism of their concerted action remains to be explained. In addition to these regulatory factors, normal mammary development and lactation require the cell-cell interaction of stromal and parenchymal elements in the mammary gland. Recent studies indicate that PRL effects on target cells are likely transmitted into cells via activation of tyrosine kinase associated with a protein-designated JAK-2, while other studies have identified stimulatory and inhibitory factors that interact with the 5' promotor regions of milk-product genes.
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