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Updated: Jul 6, 2026

Methods to Test Endocrine Disruption in Drosophila melanogaster
Published on: July 3, 2019
The aromatic hydrocarbon receptor, dioxin action, and endocrine homeostasis
1Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, CA 94305-5332, USA.
Abstract:
The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin acts through the aromatic hydrocarbon (AH) receptor to enhance CYP1A1 gene transcription. There are notable mechanistic analogies between dioxin action and lipophilic hormone action. In addition, some of dioxin's adverse effects are associated with disruptions in endocrine homeostasis. Thus, dioxin biology intersects several disciplines, including toxicology, endocrinology, molecular biology, and public health.
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