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Interaction with amyloid beta peptide compromises the lipid binding function of apolipoprotein E.

Shiori Tamamizu-Kato1, Jenny K Cohen, Carolyn B Drake

  • 1Center for the Prevention of Obesity, Cardiovascular Disease, and Diabetes, Children's Hospital Oakland Research Institute, 5700 Martin Luther King, Jr. Way, Oakland, California 94609, USA.

Biochemistry
|April 15, 2008
PubMed
Summary

Beta amyloid peptide (Abeta) interaction with apolipoprotein E C-terminal domain (apoE CT) impairs its cholesterol transport function. This Abeta association compromises lipoprotein binding, potentially impacting amyloid buildup and cholesterol accumulation.

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