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Related Concept Videos

Clearance Models: Compartment Models01:25

Clearance Models: Compartment Models

Clearance measures drug elimination from the central compartment, including plasma and highly perfused organs like kidneys and liver. Its calculation varies depending on pharmacokinetic models and administration routes. The one-compartment model, for instance, portrays the pharmacokinetics of polar drugs such as aminoglycoside antibiotics administered intravenously and readily excreted in urine. In this case, clearance is influenced by the terminal rate constant (λz) and the total volume of...
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
On...
Three-Compartment Open Model01:06

Three-Compartment Open Model

The three-compartment open model is a pharmacokinetic model used to describe the distribution and elimination of drugs following extravascular administration. It comprises a central compartment representing the plasma and two peripheral compartments. The highly perfused peripheral compartment represents organs and tissues with a rich blood supply, such as the liver, kidneys, and lungs. The scarcely perfused peripheral compartment represents tissues with lower blood supply, such as adipose...
Two-Compartment Open Model: Overview01:05

Two-Compartment Open Model: Overview

Multicompartmental models are crucial tools in pharmacokinetics, providing a framework to understand how drugs move within the body. The two-compartment model is a crucial subtype, segmenting the body into central and peripheral compartments. The central compartment represents areas with high blood flow, such as plasma and highly perfused organs like the kidneys and liver, while the peripheral compartment signifies tissues with lower blood flow, like adipose tissue and muscle tissue.
The...
Typical Model Studies01:30

Typical Model Studies

Fluid mechanics model studies often utilize scaled-down systems to predict fluid behavior in full-scale environments, such as river flows, dam spillways, and structures interacting with open surfaces. Maintaining Froude number similarity in river models is crucial, as it replicates surface flow features like wave patterns and velocities.
Clearance Models: Noncompartmental Models01:17

Clearance Models: Noncompartmental Models

Clearance is a pharmacokinetic parameter traditionally defined by compartment models, signifying the rate at which a drug is expelled from the body. However, a noncompartmental model offers an alternative method for assessing clearance, primarily employing empirical data obtained after administering a single drug dose.
The noncompartmental approach capitalizes on extensive sampling data, correlating the volume of distribution to systemic exposure and the administered dosage. This method enables...

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Related Experiment Video

Updated: Jul 6, 2026

An R-Based Landscape Validation of a Competing Risk Model
05:37

An R-Based Landscape Validation of a Competing Risk Model

Published on: September 16, 2022

VR closure rates for two vocational models.

Virginia V Fraser1, Amanda M Jones, Rochelle Frounfelker

  • 1Thresholds, Chicago, IL 60613, USA. gfraser@thresholds.org

Psychiatric Rehabilitation Journal
|April 15, 2008
PubMed
Summary
This summary is machine-generated.

Individual Placement and Support (IPS) achieved comparable vocational rehabilitation (VR) closure rates to the Diversified Placement Approach (DPA). This study found IPS is a viable supported employment model for individuals with psychiatric disabilities.

Related Experiment Videos

Last Updated: Jul 6, 2026

An R-Based Landscape Validation of a Competing Risk Model
05:37

An R-Based Landscape Validation of a Competing Risk Model

Published on: September 16, 2022

Area of Science:

  • Psychiatry
  • Rehabilitation Medicine
  • Health Services Research

Background:

  • Individual Placement and Support (IPS) is an evidence-based supported employment model for individuals with psychiatric disabilities.
  • Financial viability of IPS programs depends on funding from the state-federal vocational rehabilitation (VR) system.
  • Concerns exist regarding the compatibility of IPS principles with VR system practices.

Purpose of the Study:

  • To compare the effectiveness of the IPS model with the Diversified Placement Approach (DPA) in terms of VR sponsorship and successful closure rates.
  • To examine the compatibility of IPS with the VR system.
  • To describe a collaboration model facilitating VR sponsorship for IPS clients.

Main Methods:

  • A randomized controlled trial comparing IPS to DPA.
  • Examination of VR sponsorship rates and successful VR closures (Status 26).
  • Description of an inter-agency collaboration to expedite VR sponsorship.

Main Results:

  • Both IPS and DPA achieved a 44% rate of VR Status 26 closure.
  • IPS and DPA showed similar average times to achieve VR sponsorship.
  • Time to VR Status 26 closure was, on average, 51 days longer for IPS compared to DPA.

Conclusions:

  • Despite apparent conflicts with VR practices (e.g., zero exclusion, rapid job search), IPS demonstrates comparable closure rates to DPA.
  • The findings support the financial viability and integration of IPS within the VR system.
  • IPS is a viable supported employment model for individuals with psychiatric disabilities, achieving successful outcomes through the VR system.