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Generation and Labeling of Murine Bone Marrow-derived Dendritic Cells with Qdot Nanocrystals for Tracking Studies

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Dendritic cells augment choroidal neovascularization.

Kei Nakai¹, Ofer Fainaru, Lauren Bazinet

¹Department of Surgery, Vascular Biology Program, Children's Hospital Boston, Boston, Massachusetts 02115, USA.

Investigative Ophthalmology & Visual Science

|April 15, 2008

Summary

Dendritic cells (DCs) promote the growth of abnormal blood vessels in wet age-related macular degeneration (wet ARMD). Targeting these immune cells could offer new therapies for wet ARMD and similar conditions involving angiogenesis.

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Area of Science:

Immunology
Ophthalmology
Angiogenesis research

Background:

Dendritic cells (DCs) are innate immune cells involved in supporting angiogenesis.
Wet age-related macular degeneration (wet ARMD) is characterized by choroidal neovascularization (CNV), a form of abnormal blood vessel growth.
The role of DCs in the development of CNV has not been fully elucidated.

Purpose of the Study:

To investigate the role of dendritic cells (DCs) in the development of choroidal neovascularization (CNV).

Main Methods:

Induction of CNV in C57BL/6J mice using laser photocoagulation.
Analysis of CNV lesions for DC presence via flow cytometry and immunostaining.
Assessment of the impact of intravenous DC transplantation on CNV size.

Main Results:

Dendritic cells (DCs) transiently infiltrated CNV lesions, peaking at 2-4 days post-injury.
Immature DCs were identified within lesions and expressed vascular endothelial growth factor receptor 2.
Intravenously administered DCs were found in lesions, with immature DCs enhancing CNV size.

Conclusions:

Dendritic cells (DCs) play a role in promoting angiogenesis and lesion growth in laser-induced CNV.
DCs represent potential cellular targets for therapeutic strategies in wet ARMD.
Further research into DC-mediated angiogenesis could lead to novel treatments for neovascular eye diseases.