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Alcohol consumption is not protective for systemic lupus erythematosus
1Division of Rheumatology, Tufts Medical Center, Boston, MA 02111, USA. jwang1@tuftsmedicalcenter.org
Annals of the Rheumatic Diseases
|April 15, 2008
Summary
Alcohol consumption does not appear to protect against systemic lupus erythematosus (SLE). Individuals diagnosed with SLE are more likely to stop drinking alcohol, suggesting a change in habits rather than a protective effect.
Area of Science:
- Rheumatology
- Epidemiology
- Addiction Medicine
Background:
- Previous studies suggested alcohol drinking may be protective against systemic lupus erythematosus (SLE).
- A potential protopathic bias may explain the observed association between alcohol and SLE.
- Investigating current and pre-diagnostic alcohol consumption is crucial to understand this relationship.
Purpose of the Study:
- To investigate the association between alcohol consumption and the incidence of SLE.
- To differentiate between current and pre-diagnostic alcohol consumption in relation to SLE risk.
- To address potential protopathic bias in the alcohol-SLE association.
Main Methods:
- An Internet-based case-control study design was employed.
- Cases met >=4 American College of Rheumatology criteria for SLE, diagnosed within 5 years.
- Participants were matched using propensity scores, and alcohol consumption was assessed via online surveys. Conditional logistic regression was used for analysis.
Main Results:
- Current drinking (>=2 days/week) showed an inverse association with SLE (OR 0.35).
- Consuming >2 drinks/day was also inversely associated with SLE (OR 0.41).
- Alcohol consumption prior to SLE diagnosis was not associated with SLE risk (p>=0.4). Individuals with SLE were more likely to quit drinking before or after diagnosis.
Conclusions:
- Alcohol consumption before SLE diagnosis is not associated with SLE risk.
- Individuals who develop SLE tend to quit drinking alcohol.
- The findings suggest that changes in drinking habits, not a protective effect, may explain previous observations.
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