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Related Concept Videos

Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Cirrhosis II: Pathophysiology01:24

Cirrhosis II: Pathophysiology

Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to structural...

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Related Experiment Video

Updated: Jul 6, 2026

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
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A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

Published on: September 30, 2021

Hepatocellular carcinoma: latest developments.

Natasha Walzer1, Laura M Kulik

  • 1Feinberg School of Medicine, Division of Hepatology, Northwestern University, Chicago, Illinois, USA.

Current Opinion in Gastroenterology
|April 15, 2008
PubMed
Summary
This summary is machine-generated.

New developments in hepatocellular carcinoma (HCC) include potential prevention strategies and novel molecular markers for early diagnosis. Treatment options like resection, transplantation, and chemoembolization are evolving, requiring tailored therapies for improved survival.

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An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
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Generation of Subcutaneous and Intrahepatic Human Hepatocellular Carcinoma Xenografts in Immunodeficient Mice
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Generation of Subcutaneous and Intrahepatic Human Hepatocellular Carcinoma Xenografts in Immunodeficient Mice

Published on: September 25, 2013

Related Experiment Videos

Last Updated: Jul 6, 2026

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
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Published on: September 30, 2021

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
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An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

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Generation of Subcutaneous and Intrahepatic Human Hepatocellular Carcinoma Xenografts in Immunodeficient Mice
10:35

Generation of Subcutaneous and Intrahepatic Human Hepatocellular Carcinoma Xenografts in Immunodeficient Mice

Published on: September 25, 2013

Area of Science:

  • Hepatobiliary Medicine
  • Oncology
  • Gastroenterology

Background:

  • Hepatocellular carcinoma (HCC) remains a significant global health challenge.
  • Early detection and effective management are crucial for improving patient outcomes.

Purpose of the Study:

  • To review recent advancements in the understanding and treatment of hepatocellular carcinoma.
  • To highlight emerging strategies for prevention, diagnosis, and management of HCC.

Main Methods:

  • Literature review of current research on hepatocellular carcinoma.
  • Analysis of novel diagnostic markers and therapeutic approaches.

Main Results:

  • Identification of potential preventive strategies for HCC development.
  • Discovery of molecular markers for early HCC diagnosis in hepatitis C virus patients.
  • Ongoing debate regarding resection versus transplantation for early HCC.
  • Feasibility of expanding selection criteria beyond Milan criteria for transplantation.
  • Promising advancements in chemoembolization using drug-eluting beads.

Conclusions:

  • Further understanding of HCC pathogenesis will refine management strategies.
  • Tailored therapies based on tumor biology are essential for enhancing treatment efficacy and patient survival.