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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...

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Related Experiment Video

Updated: Jul 6, 2026

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model
12:49

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Published on: August 17, 2022

Liver transplantation: an update 2008.

Adnan Said1, Michael R Lucey

  • 1Section of Gastroenterology and Hepatology, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, Wisconsin, USA. axs@medicine.wisc.edu

Current Opinion in Gastroenterology
|April 15, 2008
PubMed
Summary

Expanding liver donor pools through live donation and extended criteria donors is crucial. Careful matching and new therapies are key to improving outcomes for liver transplantation recipients with hepatitis C and liver cancer.

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Area of Science:

  • Hepatology and Transplant Surgery
  • Organ Transplantation Research

Background:

  • Liver transplantation is vital for end-stage liver disease.
  • Increasing demand necessitates expanding donor organ availability.
  • Managing hepatitis C and hepatocellular carcinoma recurrence post-transplant is critical.

Purpose of the Study:

  • To review strategies for expanding the liver donor pool.
  • To assess outcomes of live donor liver transplantation and extended criteria donor grafts.
  • To discuss management of hepatitis C and hepatocellular carcinoma in liver transplant recipients.

Main Methods:

  • Review of current literature on donor pool expansion.
  • Analysis of outcomes for live donor and extended criteria donor liver transplantation.
  • Evaluation of pretransplant therapies and post-transplant management for hepatitis C and hepatocellular carcinoma.

Main Results:

  • Live donor liver transplantation outcomes are comparable to deceased donor transplantation.
  • Extended criteria donor grafts show reduced graft survival, especially in high-risk recipients.
  • Careful donor-recipient matching is essential for extended criteria grafts.
  • Pretransplant ablation therapy and antiviral strategies show promise for managing hepatocellular carcinoma and hepatitis C recurrence.

Conclusions:

  • Expanding the donor pool via extended criteria donors and live donation presents challenges.
  • Hepatocellular carcinoma and hepatitis C virus recurrence remain significant research areas in liver transplantation.