Related Experiment Video
Updated: Jul 6, 2026

Experimental Protocol for Examining Behavioral Response Profiles in Larval Fish: Application to the Neuro-stimulant Caffeine
Published on: July 24, 2018
Effects of different doses of caffeine on exercise responses in young children
Kenneth R Turley1, Justin R Bland, William J Evans
1Human Performance Laboratory, Department of Kinesiology, Harding University, Searcy, AR 72149, USA. KRTurley@Harding.edu
Insights
Caffeine intake in children increased blood pressure and decreased heart rate before exercise, with no significant impact on metabolism during exercise. Moderate doses did not affect substrate utilization.
Area of Science:
- Pediatric Exercise Physiology
- Nutritional Biochemistry
- Sports Science
Background:
- Caffeine is a widely consumed stimulant with known physiological effects.
- Research on caffeine's impact on young children's exercise responses is limited.
- Understanding these effects is crucial for assessing safety and performance implications.
Purpose of the Study:
- To investigate the dose-dependent effects of caffeine on physiological responses during exercise in children.
- To determine if caffeine influences heart rate, blood pressure, and metabolic responses in pediatric populations.
Main Methods:
- Forty healthy children participated in a randomized, double-blind, placebo-controlled study.
- Children received placebo (PL) or caffeine doses of 1, 3, or 5 mg.kg(-1) (CAF-1, CAF-3, CAF-5).
- Physiological measures including heart rate (HR), oxygen consumption (VO2), respiratory exchange ratio (RER), and blood pressure (BP) were recorded during rest and graded cycle ergometer exercise.
Main Results:
- Caffeine administration (especially CAF-5) led to significantly higher pre-exercise systolic and diastolic blood pressure compared to placebo.
- Heart rate was significantly lower at rest and during exercise with CAF-3 and CAF-5 compared to placebo.
- No significant effects of caffeine were observed on oxygen consumption or respiratory exchange ratio, except for a lower RER in CAF-1 versus CAF-5 during high-intensity exercise.
Conclusions:
- Caffeine intake at doses of 1-5 mg.kg(-1) did not alter substrate utilization during exercise in children.
- Caffeine increased pre-exercise blood pressure and decreased heart rate.
- A slight decrease in heart rate during exercise was observed with moderate caffeine doses (CAF-3, CAF-5).
Introduction/Purpose:
This study investigated the effects of three different doses of caffeine on physiological responses to exercise in young children.
Methods:
Forty healthy children (20 boys and 20 girls) volunteered for a random, double-blind, counterbalanced study where they received either placebo (PL), 1 mg.kg(-1) (CAF-1), 3 mg.kg(-1) (CAF-3), or 5 mg.kg(-1) (CAF-5) caffeine, 60 min prior to preexercise measures, followed by cycle ergometer exercise at 25 W and then 60% VO2peak. During this time, heart rate (HR), oxygen consumption (VO2), and respiratory exchange ratio (RER) were measured continuously, while blood pressure (BP) was measured every 2 min.
Results:
There were no significant gender x treatment interactions, and so the boys' and girls' data were combined. At preexercise, CAF-5 SBP and DBP were significantly (P < 0.05) higher than PL. Both CAF-1 and CAF-3 DBP were also significantly (P < 0.05) higher versus PL at preexercise. There were no treatment effects for exercise BP. At rest and during both exercise intensities, HR was significantly (P < 0.05) lower in CAF-3 (approximately 5 bpm) and CAF-5 (approximately 6 bpm) versus PL. There were no significant effects of CAF on metabolism (VO2 or RER) except for a lower RER in CAF-1 versus CAF-5 at 60% VO2peak.
Conclusion:
Low, mild, and moderate (1, 3, and 5 mg.kg(-1)) doses of caffeine have no effect on substrate use as reflected by RER. Further, caffeine intake resulted in an increase in BP and decrease in HR at preexercise and a slight decrease in HR with CAF-3 and CAF-5 versus PL during exercise.
More Related Videos
10:02Event Related Potentials (ERPs) and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder (ADHD)
Published on: March 12, 2020
08:22Measuring Cardiac Autonomic Nervous System (ANS) Activity in Toddlers - Resting and Developmental Challenges
Published on: February 25, 2016
Related Concept Videos
Drug Dosing: Infants and Children
Factors Affecting Drug Response: Overview
Pharmacokinetics in Pediatric Patients: Drug Metabolism
Experimental Designs
Pharmacokinetics in Pediatric Patients: Drug Excretion
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption