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Updated: Jul 6, 2026
12:59
Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
T-helper 17 cells in psoriatic plaques and additional genetic links between IL-23 and psoriasis
1Department of Dermatology, Oregon Health and Science University, Portland, Oregon, USA. blauvela@ohsu.edu
The Journal of Investigative Dermatology
|April 15, 2008
Abstract:
T-helper 17 (Th17) cells are a newly appreciated T-cell subset, distinct from both Th1 and Th2 cells, that have been implicated in the pathogenesis of psoriasis and other autoimmune inflammatory diseases (Figure 1) (Fitch et al., 2007; Kastelein et al., 2007). IL-23 stimulates survival and proliferation of Th17 cells and thus serves as a key master cytokine regulator for these diseases.
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