Related Experiment Video

Updated: Jul 6, 2026

In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones
11:36

In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones

Published on: July 25, 2019

Controlling hair follicle signaling pathways through polyubiquitination

Erik G Huntzicker1, Anthony E Oro

  • 1Program in Epithelial Biology, Stanford University, Stanford, California 94305, USA.

The Journal of Investigative Dermatology
|April 15, 2008
PubMed

Insights

Protein polyubiquitination is crucial for regulating key signaling pathways essential for hair follicle development and regeneration. This review explores how polyubiquitination controls signaling component stability and interactions during these processes.

Area of Science:

  • Developmental biology
  • Molecular signaling
  • Dermatology

Background:

  • Hair follicle formation and upkeep depend on intricate epithelial-dermal communication.
  • Key signaling pathways like Wnt, Sonic hedgehog, and NF-kappaB/Edar are vital for hair follicle development.
  • Aberrant activation of these pathways can result in skin and appendage tumors.

Purpose of the Study:

  • To review the role of protein polyubiquitination in regulating signaling pathways during hair follicle development and regeneration.
  • To elucidate how polyubiquitination influences the stability and interactions of critical signaling molecules.

Main Methods:

  • Literature review of recent research on protein polyubiquitination and hair follicle signaling.
  • Analysis of molecular mechanisms underlying polyubiquitination's impact on Wnt, Sonic hedgehog, and NF-kappaB/Edar pathways.

Main Results:

  • Protein polyubiquitination acts as a central regulator for the timing, duration, and localization of developmental signaling.
  • Polyubiquitination modulates the stability and complex interactions of key proteins within hair follicle signaling networks.
  • Dysregulation of polyubiquitination can disrupt normal hair follicle cycling and contribute to neoplasia.

Conclusions:

  • Protein polyubiquitination is indispensable for the precise control of signaling essential for hair follicle development and regeneration.
  • Understanding polyubiquitination's role offers insights into potential therapeutic strategies for hair disorders and skin cancers.

More Related Videos

Comparative Strategies for Ubiquitination Detection in Mammalian Cell Lysates Using SMAD2/SMURF2 as a Model09:00

Comparative Strategies for Ubiquitination Detection in Mammalian Cell Lysates Using SMAD2/SMURF2 as a Model

Published on: April 17, 2026

Evaluation of Substrate Ubiquitylation by E3 Ubiquitin-ligase in Mammalian Cell Lysates09:47

Evaluation of Substrate Ubiquitylation by E3 Ubiquitin-ligase in Mammalian Cell Lysates

Published on: May 10, 2022

Related Concept Videos

Regulated Protein Degradation02:58

Regulated Protein Degradation

It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a balance between their rate of synthesis and degradation or regulating the intrinsic activity of the protein. Both these regulation mechanisms play an essential role in the normal functioning of cells.
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a rapamycin-insensitive companion...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein.