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Testis-determining factor and Y-linked sex reversal
J R Hawkins1, P Koopman, P Berta
1Human Molecular Genetics Laboratory, Imperial Cancer Research Fund, London, UK.
Current Opinion in Genetics & Development
|June 1, 1991
Abstract:
A gene named SRY, isolated last year from the sex-determining region of the human Y chromosome, satisfies many of the criteria expected of the testis-determining factor gene. Mutations in SRY have been found in XY females, strongly implicating SRY as the testis-determining gene.